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31.
Abstract Synthesis of biologically active oligosaccharides, haptens and their protein conjugates is a major area of interest because of their role in antigen-antibody interaction and receptor effects1. A number of these molecules contain α-or β-linked 2-acetamido-2-deoxy-D-glucosamine (GlcNAc) moieties. Most commonly, during the oligosaccharide synthesis, introduction of the β-glycosidically linked GlcNAc residue is achieved by either the oxazoline2 or the phthalimido method3. Of these, the latter is preferred because 2-N-phthalimido protected glycosamine units having a halogen or a thioalkyl group at C-1 have consistently proved to be more efficient donors than are the oxazolines. However, time and again, subsequent conversion of the N-phthalimido to amine by hydrazinolysis has proved inadequate. This has often resulted in a poor overall yield after an otherwise efficient synthesis. Recently it was shown that the phthalimido function could be removed under mild conditions from a number of amino acids4. We now report that this technique can be efficiently used for the deprotection of the phthalimido function in suitably protected carbohydrate compounds (2,3 and 5). 相似文献
32.
Somnath Dasgupta‡ Vishal Kumar Rajput‡ Bimalendu Roy 《Journal of carbohydrate chemistry》2013,32(2):91-106
Lanthanum trifluoromethanesulfonate‐catalyzed solvent‐free per‐O‐acetylation with stoichiometric acetic anhydride proceeds in high yield (95%–99%) to afford exclusively pyranose products as anomeric mixtures. Subsequent anomeric substitution employing borontrifluoride etherate and thiols or alcohols furnished the corresponding 1,2‐trans‐linked thioglycosides and O‐glycosides, respectively, in good to excellent overall yield (75%–85%). Alternatively, reaction of free sugars in neat alcohol employing the same catalyst at elevated temperature gives the corresponding 1,2‐cis‐linked O‐glycosides (along with 1,2‐trans‐linked glycosides as minor product) in good yield (73%–80%). Anomeric mixtures of compounds thus produced were characterized as their per‐O‐acetylated derivatives. 相似文献
33.
Samit Bera Bhaskar Das Arnab De Atish Barua Susmita Das Bratati De 《Natural product research》2020,34(4):599-603
AbstractThe methanolic extract of Cycas revoluta cone (MECR) was analyzed by GC-MS and UHPLC for metabolite profiling and was evaluated for anti-colon cancer property by using in vitro assays like Cell Viability Assay, Colony Formation Assay, ROS Determination, Flowcytometry, DAPI staining assay, Tunel assay. GC-MS and HPLC analysis confirmed the presence of different phytochemicals in the extract of Cycas revoluta cone. In-vitro studies showed MECR extract showed significant anti-colon cancer activity by reducing proliferation and inducing apoptosis in colon cancer cell (HCT-8) line, but no such activity was seen in normal colon cell (CCD-18Co) line. The investigation confirms that MECR may be a promising candidate in colon cancer protection. 相似文献
34.
Arundhati Dasgupta 《General Relativity and Gravitation》2011,43(8):2237-2255
I give a resolution of the conformal mode divergence in the Euclidean gravitational path-integral by isolating the trace of
the diffeomorphisms and its contribution to the Faddeev-Popov measure. 相似文献
35.
A neural network model that exhibits stochastic population bursting is studied by simulation. First return maps of interburst intervals exhibit recurrent unstable-periodic-orbit(UPO)-like trajectories similar to those found in experiments on hippocampal slices. Applications of various control methods and surrogate analysis for UPO detection also yield results similar to those of experiments. Our results question the interpretation of the experimental data as evidence for deterministic chaos and suggest caution in the use of UPO-based methods for detecting determinism in time-series data. 相似文献
36.
37.
Surajit?Dasgupta Neven?Bilic Tapas?K.?DasEmail author 《General Relativity and Gravitation》2005,37(11):1877-1890
We demonstrate that a spherical accretion onto astrophysical black holes, under the influence of Newtonian or various post-Newtonian
pseudo-Schwarzschild gravitational potentials, may constitute a concrete example of classical analogue gravity naturally found
in the Universe. We analytically calculate the corresponding analogue Hawking temperature as a function of the minimum number
of physical parameters governing the accretion flow. We study both the polytropic and the isothermal accretion. We show that
unlike in a general relativistic spherical accretion, analogue white hole solutions can never be obtained in such post-Newtonian
systems. We also show that an isothermal spherical accretion is a remarkably simple example in which the only one information–the
temperature of the fluid, is sufficient to completely describe an analogue gravity system. For both types of accretion, the
analogue Hawking temperature may become higher than the usual Hawking temperature. However, the analogue Hawking temperature
for accreting astrophysical black holes is considerably lower compared with the temperature of the accreting fluid. 相似文献
38.
Large-Scale Production of 3D Bioactive Glass Macroporous Scaffolds for Tissue Engineering 总被引:3,自引:0,他引:3
Julian R. Jones Samit Ahir Larry L. Hench 《Journal of Sol-Gel Science and Technology》2004,29(3):179-188
For tissue engineering applications, a scaffold is required that can act as a template and guide for cell proliferation, cell differentiation and tissue growth. Interconnected pores with diameters greater than 100 m are required for tissue ingrowth, vascularisation and nutrient delivery to the centre of the scaffold. 3D bioactive glass scaffolds have been produced, by foaming sol-gel derived bioactive glasses. The method to produce foams with a modal macropore diameter of 100 m, and a handling strength suitable for cell culture, was to foam 50 ml batches of sol with the aid of a surfactant and gelling agent. In vitro and in vivo tests show that the scaffolds have high potential to be used in bone tissue engineering applications. Larger batches are required to produce scaffolds commercially. The aim of this work was to investigate how the process could be up-scaled for commercial use. This study shows that foaming larger aliquots of sol decreased the scaffold porosity and interconnectivity and investigates methods of modifying the process to obtain large quantities of foam scaffolds with pores in excess of 100 m. The optimum method to produce foams of similar pore structure from 200 ml sol to those produced from 50 ml sol comprised of adding 3 ml surfactant and 12 ml dionised water to the sol to start foaming and injecting a gas mixture (70% helium, 30% nitrogen) at 0.2 bar while applying vigorous agitation. 相似文献
39.
S.?Dey S.S.?Dasgupta C.C.?Dey P.?Bhattacharya 《The European Physical Journal A - Hadrons and Nuclei》2003,16(2):193-197
A kinematically complete experiment has been performed to study the α-n final-state interaction (FSI) in the α + d ↦α + p
+ n break-up reaction at 50 MeV incident energy for the alpha-particles. For this, we have chosen four pairs of correlation
angles for the outgoing alpha and protons. These are ( θα = 18°, θp = 42°), ( θα = 20°, θp = 45°), ( θα = 22°, θp = 42°) and ( θα = 22°, θp = 47°), selected kinematically where the allowed phase spaces are in favor of the α-n final-state interaction. Our experimental
data show strong α-n FSI in all the selected configurations. Also, the FSI is found to be stronger at the lower alpha-particle
energy when two FSI peaks appear in the same configuration.
Received: 17 June 2002 / Accepted: 3 October 2002 / Published online: 4 February 2003
RID="a"
ID="a"e-mail: dey_s2001@yahoo.com; Present address: 445 Waupelani Drive, Apt. F3, State College, PA 16801, USA.
Communicated by M. Gar?on 相似文献
40.
Mrinmay Pal Somnath Bandyopadhyay Palas Biswas Rimlee Debroy M. C. Paul Ranjan Sen Kamal Dasgupta S. K. Bhadra 《Optical and Quantum Electronics》2007,39(14):1231-1243
In this paper, gain flatness is studied for simultaneous 16-ITU-T channel amplifications at C-band (1,532–1,558 nm) in a single
stage EDFA for WDM application at different average inversion levels. The inversion levels are varied due to the change of
the input signal levels from the targeted operating point and also for dropping few numbers of channels. Specially designed
gain flattening filter (GFF) is used in order to get the flat gain with gain variation ±0.5 dB for −20 dBm/ch input signal
power (total input signal power is −8.0 dBm) at a fixed average inversion level which is maintained by proper selection of
optimum fibre length and pump power. A specific loss spectrum of GFF is obtained by writing a chirped fibre Bragg grating
of length 20 mm. Gain variations are studied by changing the total input signal levels from −8.0 dBm to −20.0 dBm and maintained
within 20.0 ± 0.5 dB by using automatic gain control (AGC) circuit. About 15 out of 16 channels are dropped and observed ±
0.5 dB gain-variation which is an important parameter in optical network system. 相似文献